pantoprazole Intravenous

pan-TOE-pra-zole

Commonly used brand name(s)

In the U.S.

• Protonix


• Protonix IV

Available Dosage Forms:

• Powder for Solution

Pharmacologic Class: Proton Pump Inhibitor

Uses For pantoprazole

Pantoprazole injection is used to treat certain conditions in which there is too much acid in the stomach. It is used for short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD) with a history of erosive esophagitis. GERD is a condition in which the acid in the stomach washes back up into the esophagus. pantoprazole may also be used to treat Zollinger-Ellison syndrome or other conditions (e.g., cancer) in which the stomach produces too much acid.

Pantoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.

pantoprazole is available only with your doctor's prescription.

Before Using pantoprazole

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pantoprazole, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pantoprazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pantoprazole injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pantoprazole injection in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving pantoprazole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using pantoprazole with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Rilpivirine

Using pantoprazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Atazanavir


• Citalopram


• Dasatinib


• Erlotinib


• Methotrexate


• Mycophenolate Mofetil


• Nelfinavir


• Nilotinib

Using pantoprazole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Cranberry


• Itraconazole


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of pantoprazole. Make sure you tell your doctor if you have any other medical problems, especially:

• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Osteoporosis (bone problem) or


• Zinc deficiency—Use with caution. May make these conditions worse.

Proper Use of pantoprazole

A nurse or other trained health professional will give you pantoprazole in a clinic or hospital. pantoprazole is given through a needle placed in one of your veins.

It may take several days before pantoprazole begins to relieve stomach pain. To help relieve this pain, antacids may be taken with pantoprazole, unless your doctor has told you not to use them.

Tell your doctor if you have had problems with a lack of zinc in your body. Your doctor may want you to take zinc supplements.

Your doctor will give you a few doses of pantoprazole until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using pantoprazole

It is important that your doctor check your progress at regular visits. If your condition does not improve, or if it becomes worse, check with your doctor.

pantoprazole may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive the medicine.

pantoprazole may cause thrombophlebitis. Check with your doctor right away if you notice any of these side effects at the injection site: changes in skin color, pain, tenderness, or swelling of the foot or leg.

Pantoprazole injection may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of pantoprazole, or use it for one year or more.

Do not stop using pantoprazole without first checking with your doctor, or unless told to do so by your doctor.

Make sure any doctor or dentist who treats you knows that you are using pantoprazole. pantoprazole may affect the results of certain medical tests.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription (e.g., atazanavir, Reyataz®) or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

pantoprazole Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

• Accumulation of pus


• bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site


• changes in skin color, pain, tenderness, or swelling of the foot or leg


• fever


• stomach pain


• swollen, red, tender area of infection

Incidence not known

• Abdominal or stomach pain


• absence of or decrease in body movement


• blindness


• blistering, peeling, or loosening of the skin


• bloating of abdomen or stomach


• bloody or cloudy urine


• bloody, black, or tarry stools


• blurred vision


• chills


• constipation


• continuing ringing or buzzing or other unexplained noise in the ears


• cough


• dark-colored urine


• decreased vision


• diarrhea


• difficulty with speaking


• difficulty with swallowing


• dizziness or lightheadedness


• fast heartbeat


• feeling of constant movement of self or surroundings


• greatly decreased frequency of urination or amount of urine


• hearing loss


• hives


• increased watering of the mouth


• indigestion


• itching


• joint or muscle pain


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• light-colored stools


• loss of appetite


• mood or mental changes


• muscle cramps or spasms


• muscle pain or stiffness


• nausea or vomiting


• pains in the stomach, side, or abdomen, possibly radiating to the back


• pale skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• red skin lesions, often with a purple center


• red, irritated eyes


• sensation of spinning


• shortness of breath


• skin rash


• sore throat


• sores, ulcers, or white spots on the lips or in the mouth


• swelling of the feet or lower legs


• swollen glands


• tightness in the chest


• unexplained bleeding or bruising


• unusual tiredness or weakness


• vomiting


• wheezing


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• belching


• dizziness


• headache


• heartburn


• indigestion


• runny nose


• sleeplessness


• sneezing


• stomach discomfort, upset, or pain


• stuffy nose


• trouble sleeping


• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: pantoprazole Intravenous side effects (in more detail)

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More pantoprazole Intravenous resources

• Pantoprazole Intravenous Side Effects (in more detail)
• Pantoprazole Intravenous Use in Pregnancy & Breastfeeding
• Drug Images
• Pantoprazole Intravenous Drug Interactions
• Pantoprazole Intravenous Support Group
• 35 Reviews for Pantoprazole Intravenous - Add your own review/rating

Compare pantoprazole Intravenous with other medications

• Barrett's Esophagus
• Duodenal Ulcer
• Erosive Esophagitis
• GERD
• Helicobacter Pylori Infection
• Peptic Ulcer
• Stomach Ulcer
• Stress Ulcer Prophylaxis
• Zollinger-Ellison Syndrome